In vitro antifungal activity of new series of homoallylamines and related compounds with inhibitory properties of the synthesis of fungal cell wall polymers

LEONOR Y. VARGAS; MARÍA V. CASTELLI; VLADIMIR V. KOUZNETSOV; JUAN M. URBINA; SILVIA N. LÓPEZ; MAXIMILIANO SORTINO; RICARDO D. ENRIZ; JUAN C. RIBAS; SUSANA ZACCHINO

BIOORGANIC & MEDICINAL CHEMISTRY.

Elsevier Ltd

Lugar: San Diego, CA; Año: 2003 vol. 11 p. 1531 - 1550

0968-0896

The synthesis, in vitro antifungal evaluation and SAR studies of 101 compounds of the 4-aryl-, 4-alkyl-, 4-pyridyl or -quinolinyl-4-N-arylamino-1-butenes series and related compounds, are reported here. Active structures showed to inhibit (1,3)-b-D-glucan and mainly chitin synthases, enzymes that catalyze the synthesis of the major fungal cell wall polymers.