INVESTIGADORES
SORTINO Maximiliano Andres
artículos
Título:
Structureactivity relationship study of homoallylamines
Autor/es:
FERNANDO D. SUVIRE; MAXIMILIANO SORTINO; VLADIMIR V. KOUZNETSOV; LEONOR Y. VARGAS; SUSANA A. ZACCHINO; URIEL MORA CRUZ; RICARDO D. ENRIZ
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Editorial:
Elsevier Ltd
Referencias:
Lugar: San Diego, CA; Año: 2006 vol. 14 p. 1851 - 1862
ISSN:
0968-0896
Resumen:
The synthesis, in vitro evaluation, and structureactivity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.
