The role of natural products for the discovery of new ant-infective agents, with emphasis in antifungal compounds

MAXIMILANO SORTINO; DERITA, MARCOS; SVETAZ, LAURA; RAIMONDI, MARCELA; DI LIBERTO, MELINA; PETENATTI, ELISA; MAHABIR GUPTA; SUSANA A. ZACCHINO

Bioactives and Drug Discovery: Principles, Practice, and Perspectives

Wiley

Año: 2012; p. 205 - 239

Infectious diseases have had an enormous impact throughout the centuries representing 25% of the disease burden in the adult population, partly as a result of the HIV/ AIDS epidemic. At present, they represent a significant cause of morbidity and mortality worldwide, remaining the leading cause of pediatric mortality in most developing countries. Unfortunately, the arsenal of available antimicrobial agents for the treatment of infectious diseases is insufficient to protect people over the long term. The main reasons for this poor prognosis are the unavoidable antimicrobial resistance, the new emerging infections and the re-emergence of old ones. This chapter includes the antifungal currently in use, the need of new antifungals, the sources of new antifungal and the different mechanisms of action.