Bioactive alkyl phenols and embelin from Oxalis erythrorhiza

GABRIELA EGLY FERESIN; ALEJANDRO TAPIA; MAXIMILIANO SORTINO; SUSANA ZACCHINO; ANTONIETA ROJAS DE ARIAS; ALBA INCHAUSTI; GLORIA YALUFF; JAIME RODRIGUEZ; CRISTINA THEODULOZ; GUILLERMO SCHMEDA-HIRSCHMANN

JOURNAL OF ETHNOPHARMACOLOGY

Elsevier Ltd

Lugar: Leiden (Holanda); Año: 2003 vol. 88 p. 241 - 247

0378-8741

The benzoquinone embelin and four alkyl phenols were isolated from an Argentinean collection of Oxalis erythrorhiza. 3-Heptadecyl-5-methoxy-phenol is reported for the first time. The structures were determined by spectroscopic methods. Embelin presented inhibitory effect on methicillin-resistant Staphylococcus aureus, Escherichia coli and the dermatophytic fungi Epidermophyton floccosum, Microsporum canis, Microsporum gypseum, Trichophyton mentagrophytes and Trichophyton rubrum with MICs ranging between 50 and 100_g/ml. Furthermore, embelin was active against Trypanosoma cruzi trypomastigotes with 100% lysis at 100_g/ml and cytotoxicity below the trypanocidal concentration. The new alkyl phenol 3-heptadecyl-5-methoxy-phenol was active towards Leishmania amazonensis and Leishmania donovani promastigotes with 100% lysis at 100ug/ml. The cytotoxicity (IC50) of embelin and the new alkyl phenol on human lung fibroblasts were 739 and 366uM, respectively. The plant is used to treat heart complains, a symptomatology related to Chagas’ disease which is endemic in the San Juan Province, Argentine