INVESTIGADORES
SORTINO Maximiliano Andres
artículos
Título:
Naftifine-analogues as anti-Trypanosoma cruzi agents.
Autor/es:
ALEJANDRA GERPE; LUCÍA BOIANI; HERNANDEZ L; MAXIMILANO SORTINO; SUSANA ZACCHINO; GONZALEZ, M; HUGO CERECETTO
Revista:
EUROPEAN JOURNAL OF MEDICAL CHEMISTRY
Editorial:
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Referencias:
Año: 2010 vol. 45 p. 2154 - 2164
ISSN:
0223-5234
Resumen:
Chagas disease represents a relevant health problem in Central and South America. The first line of
treatment is Nifurtimox and Benznidazole which have a great deal of disadvantages that demands the
rapid generation of therapeutic alternatives. Based in our research on aza-thiaheterocycles as anti-Trypanosoma
cruzi agents we identified pharmacophores that act through oxidative stress. Here, we describe
the synthesis and the activity of new containing bioactive-heterocycles analogues of naftifine as potential
the synthesis and the activity of new containing bioactive-heterocycles analogues of naftifine as potential
the synthesis and the activity of new containing bioactive-heterocycles analogues of naftifine as potential
cruzi agents we identified pharmacophores that act through oxidative stress. Here, we describe
the synthesis and the activity of new containing bioactive-heterocycles analogues of naftifine as potential
the synthesis and the activity of new containing bioactive-heterocycles analogues of naftifine as potential
the synthesis and the activity of new containing bioactive-heterocycles analogues of naftifine as potential
cruzi agents we identified pharmacophores that act through oxidative stress. Here, we describe
the synthesis and the activity of new containing bioactive-heterocycles analogues of naftifine as potential
the synthesis and the activity of new containing bioactive-heterocycles analogues of naftifine as potential
the synthesis and the activity of new containing bioactive-heterocycles analogues of naftifine as potential
Trypanosoma
cruzi agents we identified pharmacophores that act through oxidative stress. Here, we describe
the synthesis and the activity of new containing bioactive-heterocycles analogues of naftifine as potential
the synthesis and the activity of new containing bioactive-heterocycles analogues of naftifine as potential
the synthesis and the activity of new containing bioactive-heterocycles analogues of naftifine as potential
agents we identified pharmacophores that act through oxidative stress. Here, we describe
the synthesis and the activity of new containing bioactive-heterocycles analogues of naftifine as potential
T. cruzi membrane sterol biosynthesis inhibitors. Benzimidazole 1,3-dioxides (11 and 13) and quinoxaline
1,4-dioxides (22 and 23) displayed excellent parasite/mammal selectivity indexes. Analysis of the free
sterols from parasite incubated with the compounds showed that any of them are able to accumulate
squalene suggesting that in the anti-T. cruzi mechanism of action is not involved the inhibition of sterol
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
sterols from parasite incubated with the compounds showed that any of them are able to accumulate
squalene suggesting that in the anti-T. cruzi mechanism of action is not involved the inhibition of sterol
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
sterols from parasite incubated with the compounds showed that any of them are able to accumulate
squalene suggesting that in the anti-T. cruzi mechanism of action is not involved the inhibition of sterol
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
1,4-dioxides (22 and 23) displayed excellent parasite/mammal selectivity indexes. Analysis of the free
sterols from parasite incubated with the compounds showed that any of them are able to accumulate
squalene suggesting that in the anti-T. cruzi mechanism of action is not involved the inhibition of sterol
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
sterols from parasite incubated with the compounds showed that any of them are able to accumulate
squalene suggesting that in the anti-T. cruzi mechanism of action is not involved the inhibition of sterol
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
sterols from parasite incubated with the compounds showed that any of them are able to accumulate
squalene suggesting that in the anti-T. cruzi mechanism of action is not involved the inhibition of sterol
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
1,4-dioxides (22 and 23) displayed excellent parasite/mammal selectivity indexes. Analysis of the free
sterols from parasite incubated with the compounds showed that any of them are able to accumulate
squalene suggesting that in the anti-T. cruzi mechanism of action is not involved the inhibition of sterol
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
sterols from parasite incubated with the compounds showed that any of them are able to accumulate
squalene suggesting that in the anti-T. cruzi mechanism of action is not involved the inhibition of sterol
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
sterols from parasite incubated with the compounds showed that any of them are able to accumulate
squalene suggesting that in the anti-T. cruzi mechanism of action is not involved the inhibition of sterol
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
membrane sterol biosynthesis inhibitors. Benzimidazole 1,3-dioxides (11 and 13) and quinoxaline
1,4-dioxides (22 and 23) displayed excellent parasite/mammal selectivity indexes. Analysis of the free
sterols from parasite incubated with the compounds showed that any of them are able to accumulate
squalene suggesting that in the anti-T. cruzi mechanism of action is not involved the inhibition of sterol
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
sterols from parasite incubated with the compounds showed that any of them are able to accumulate
squalene suggesting that in the anti-T. cruzi mechanism of action is not involved the inhibition of sterol
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
sterols from parasite incubated with the compounds showed that any of them are able to accumulate
squalene suggesting that in the anti-T. cruzi mechanism of action is not involved the inhibition of sterol
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
22 and 23) displayed excellent parasite/mammal selectivity indexes. Analysis of the free
sterols from parasite incubated with the compounds showed that any of them are able to accumulate
squalene suggesting that in the anti-T. cruzi mechanism of action is not involved the inhibition of sterol
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.
T. cruzi mechanism of action is not involved the inhibition of sterol
biosynthesis. Some derivatives were also tested as antifungal agents. The results obtained in the present
work open potential therapeutic possibilities of new compounds for these infectious diseases.