Synergistic antifungal effectiveness of essential oils from andean plants combined with commercial drugs

LIMA, B.; SORTINO M; TAPIA, A.; FERESIN, G

International Journal of Pharmaceutical Sciences and Developmental Research

Peertechz Publications

Lugar: Los Angeles; Año: 2022

The appearance of antifungal resistance promotes the investigation of therapeutic options. There are few studies on the combined effect of antifungal drugs andessential oils (EOs). In the present work, regarding the association of eight EOs Andean plants with antifungal agents against a panel of fungi strains. Combinatorialeffects were determined using the Fractional Inhibitory Concentration Index (FICI) and Dose Reduction Index (DRI). A combination of A. cryptantha-B EO with fl uconazoleshowed a synergistic effect against C. Albicans (FIC = 0.31 and DRI = 16.25). EOs from A. cryptantha-A and L. integrifolia showed an additive effect (FICI = 0.75) against C.neoformans. A combination of EOs from A. seriphioides and A. cryptantha-A with terbinafi ne showed an additive effect on T. rubrum (FIC = 0.56; DRI = 16) and M. gypseum(FICI = 1.03; DRI = 32). In conclusion, combinations between EOs of species from Andean plants and commercial antifungal drugs yielded some interesting fi ndings, aspotential antifungal strategies used for treating infections associated with C. albicans and T. rubrum.