Metabolic profiling of biofluids in fish for identifying biomarkers of exposure and effects for assessing aquatic pollution

CARRIQUIRIBORDE, P.

Environmental Metabolomics Applications in Field and Laboratory Studies to Understand from Exposome to Metabolome

Elsevier Inc

Lugar: Oxford; Año: 2020; p. 65 - 82

Biofluids can be defined as the liquid media produced by multicellular organism?s cells that circulate through vessels or body cavities (such as blood or cerebrospinal fluid), excreted (such as urine or sweat) or secreted (such as breast milk or bile), or developed as a result of a pathological process (such as blister or cyst fluid). The metabolic composition of biofluids closely reflects the physiological status of the organisms. Today, it is wellknown in medicine that plasma glucose will increase above basal levels after a meal (Meyer et al., 1971), that plasmatic cortisol levels will decrease below basal levels after repeated traumatic situation (Steudte-Schmiedgen et al., 2016), or that the presence of bilirubin in human urine is consistent with liver injuries (Foley and Wasserman, 2014).