INVESTIGADORES
ALARCON laureano Martin
artículos
Título:
Effects of hydroxy-xanthones on dipalmitoylphosphatidylcholine lipid bilayers: A theoretical and experimental study
Autor/es:
M.B. SIERRA; L.M. ALARCÓN; D. GERBINO; V.I. PEDRONI; F.E. BUFFO; M.A. MORINI
Revista:
CHEMISTRY AND PHYSICS OF LIPIDS
Editorial:
ELSEVIER IRELAND LTD
Referencias:
Lugar: Amsterdam; Año: 2017 vol. 206 p. 1 - 8
ISSN:
0009-3084
Resumen:
Xanthonesandderivativesarenaturalactivecompoundswhoseinteresthasbeenincreasedduetoitsseveralpharmacologicaleffects.Inthiswork,effectsofhydroxy-xanthonesonthephysicochemicalpropertiesofdipalmitoylphosphatidylcholine(DPPC)liposomeshavebeeninvestigatedintermsoflipidbilayerfluidity,bymeansofmoleculardynamicssimulationsandtemperaturedependenceofzetapotentialstudies.Experimentalresultspredict,ingoodagreementwithsimulations,thatxanthonesareabletobeincorporatedintoDPPCliposomeswithcertainlocalization,fluidizingthebilayer.Botheffects,localizationandfluiditywerefoundtobedependentofthenumberofhydroxilicsubstituentsofthexanthoneandthelipidphaseXanthonesandderivativesarenaturalactivecompoundswhoseinteresthasbeenincreasedduetoitsseveralpharmacologicaleffects.Inthiswork,effectsofhydroxy-xanthonesonthephysicochemicalpropertiesofdipalmitoylphosphatidylcholine(DPPC)liposomeshavebeeninvestigatedintermsoflipidbilayerfluidity,bymeansofmoleculardynamicssimulationsandtemperaturedependenceofzetapotentialstudies.Experimentalresultspredict,ingoodagreementwithsimulations,thatxanthonesareabletobeincorporatedintoDPPCliposomeswithcertainlocalization,fluidizingthebilayer.Botheffects,localizationandfluiditywerefoundtobedependentofthenumberofhydroxilicsubstituentsofthexanthoneandthelipidpha
