Paving the way for adequate myelination: the contribution of Galectin-3, Transferrin and Iron

PAULA G. FRANCO 1, LAURA A. PASQUINI 1, MARÍA J. PÉREZ 1, MARÍA V. ROSATO-SIRI 1, LUCAS SILVESTROFF 1, JUANA M. PASQUINI

FEBS LETTERS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2015

0014-5793

Considering the worldwide incidence of well characterized demyelinating disorders such asMultiple Sclerosis (MS) and the increasing number of pathologies recently found to involvehypomyelinating factors such as micronutrient deficits, elucidating the molecular basis of centralnervous system (CNS) demyelination, remyelination and hypomyelination becomes essential tothe development of future neuroregenerative therapies. In this context, this review discusses novelfindings on the contribution of galectin-3 (Gal-3), transferrin (Tf) and iron to the processes of myelinationand remyelination and their potentially positive regulation of oligodendroglial precursor cell(OPC) differentiation. Studies were conducted in cuprizone (CPZ)-induced demyelination and irondeficiency (ID)-induced hypomyelination, and the participation of glial and neural stem cells(NSC) in the remyelination process was evaluated by means of both in vivo and in vitro assays onprimary cell cultures