Endothelial effects of magnetic nanocarriers composed by magnetite, oleic acid and chitosan intended to drug delivery devices

MARIELA AGOTEGARAY; ADRIÁN CAMPELO; VIRGINIA MASSHEIMER; VERONICA LASSALLE

Congreso; Reunión Internacional de Ciencias Farmaceúticas; 2014

Magnetic nanoparticles (MNPs) are promising systems intended for target and delivery of several drugs due to their ability to orient the therapeutic agent to the desired part of the body by the application an external magnetic field. Two magnetic nanodevices were evaluated in culture of endothelial cells (ECs) to study the cell viability. Formulations consist in a magnetic core composed by magnetite functionalized with oleic acid and recovered with crosslinked (N1) and non-crosslinked chitosan (N2).