Numerical Modelling of the mass transport of blood-borne species in cerebral aneurysms of the basilar artery.

J. A. COSTELLOE; I. LARRABIDE; A. F. FRANGI; M. T. WALSH

Sunriver

Conferencia; ASME 2013 Summer Bioengineering Conference; 2013

The use of computational modelling for the investigation of flow dynamics within cerebral aneurysms has become more widespread [4]. In cases where some or all patient-specific data is not available, the use of representative geometries based on patient-specific models provides an attractive alternative for detailed hemodynamic studies to identify key geometric parameters that indicate a higher risk of aneurysm rupture. The hypothesis motivating this study is that local hemodynamics within an aneurysm may become altered over time, potentially modifying the mass transport of blood-borne species to specific locations at the aneurysm wall. A lack of species at the wall may result in negative wall remodeling, weakening and aneurysm growth and rupture. The aims of this study are two-fold: firstly, to develop representative geometries of the basilar artery based on patient-specific models, and secondly to undertake a numerical analysis of the changes in concentration of species at the aneurysm wall.