Towards the validation of a virtual coiling technique using a real versus a simulated bolus injection

H. MORALES; I. LARRABIDE; M.C. VILLA-URIOL; A. J. GEERS; A. F. FRANGI

Fairfax

Conferencia; 2nd International Conference on Mathematical and Computational Biomedical Engineering (CMBE), 2011,; 2011

George Mason University

Endovascular coiling is a well-established therapy to treat intracranial aneurysms. However, its outcome is not always predictable. The purpose of this work is to present the first step towardsthe validation of a virtual coiling technique based on the comparison of in vivo medical imagesand computational fluid dynamics (CFD) modeling with a bolus injection. A patient harboringa coiled aneurysm was selected. A three-dimensional vascular geometry derived from medicalimage was used. The aneurysm geometry was virtually coiled using a technique that dynamicallyplans the path that each coil would follow during their insertion. Afterwards, a CFD model wasconstructed simulating the bolus injection using the time-intensity curves (TIC) obtained from adigital subtracted angiography image sequence. A qualitative comparison between real and virtualangiographic images, and the quantitative differences between TIC were assessed. As a result,the CFD model properly reproduced the global aspects of the injected contrast agent along thevascular model, including the branches downstream the coiled aneurysm.