Clinical, MRI and dipole localization analysis in different subtypes of malformations of cortical development (MCD)”

KOCHEN S, PAPAYANNIS C, LAFORCADA H, CONSALVO D, SILVA W, SAN MARTIN P, VON ELLENIUEDER N, MURAVCHIK C

Clin Neurophys

Año: 2007

Purpose: The MCD represents the second cause of refractory epilepsy in adults. Clinical, epidemiological and localization of the epileptogenic zone, through dipole localization, of the different subtypes were compared. Methods: For the dipole localization, our work group developed software that allowed optimizing the application of Polhemus and BESA. The EEG (10-10 system) were obtained for 3 hours with 64 channels (Stellate). The patients were divided in 3 groups: G1: Abnormal proliferation (cortical focal dysplasia and neoplasias), G2: Abnormal migration (heterotopias), and G3: Abnormal organization (polimicrogirias). We analyzed different variables, particularly the occurrence of gradient of divergence (GD) clinical-MRI-dipole localization. Results: We included 80 patients. G1 (n=40): women 42.5%, neurological deficit (ND) 7.5%, GD 12.5%. G2 (n=24): women 75%, ND 8.3%, GD 16.7%. G3 (n=16): women 43.7%, ND 75%, GD 31.2%. Conclusions: We founded between the subtypes of MCD significant difference in relation to sex, women´s majority in G2, the neurological deficit in G3. And we observed a gradient of divergence minor in G1 and most important in G3, correspond with the worst post-surgical prognostic in these last ones. Results: We included 80 patients. G1 (n=40): women 42.5%, neurological deficit (ND) 7.5%, GD 12.5%. G2 (n=24): women 75%, ND 8.3%, GD 16.7%. G3 (n=16): women 43.7%, ND 75%, GD 31.2%. Conclusions: We founded between the subtypes of MCD significant difference in relation to sex, women´s majority in G2, the neurological deficit in G3. And we observed a gradient of divergence minor in G1 and most important in G3, correspond with the worst post-surgical prognostic in these last ones. dysplasia and neoplasias), G2: Abnormal migration (heterotopias), and G3: Abnormal organization (polimicrogirias). We analyzed different variables, particularly the occurrence of gradient of divergence (GD) clinical-MRI-dipole localization. Results: We included 80 patients. G1 (n=40): women 42.5%, neurological deficit (ND) 7.5%, GD 12.5%. G2 (n=24): women 75%, ND 8.3%, GD 16.7%. G3 (n=16): women 43.7%, ND 75%, GD 31.2%. Conclusions: We founded between the subtypes of MCD significant difference in relation to sex, women´s majority in G2, the neurological deficit in G3. And we observed a gradient of divergence minor in G1 and most important in G3, correspond with the worst post-surgical prognostic in these last ones. significant difference in relation to sex, women´s majority in G2, the neurological deficit in G3. And we observed a gradient of divergence minor in G1 and most important in G3, correspond with the worst post-surgical prognostic in these last ones. The clinical information, MRI and the source localization methods proved useful in distinguish the differences and the prognosis in the patients with MCD. .