Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain

FERNANDO KASANETZ; THOMAS NEVIAN

Scientific Reports

Springer Natrure

Año: 2021 vol. 11

Neuropathic pain induces changes in neuronal excitability and synaptic connectivity in deep layers of the anterior cingulate cortex (ACC) that play a central role in the sensory, emotional and affective consequences of the disease. However, how this impacts ACC in vivo activity is not completely understood. Using a mouse model, we found that neuropathic pain caused an increase in ACC in vivo activity, as measured by the indirect activity marker c-Fos and yuxtacellular electrophysiological recording. The enhanced firing rate of ACC neurons in lesioned animals was associated with a change in the firing pattern towards bursting activity. Despite the proportion of ACC neurons recruited by noxious stimuli was unchanged during neuropathic pain, responses to noxious stimuli were characterized by increased bursting. Thus, this change in coding pattern may have important implications for the processing of nociceptive information in the ACC and could be of great interest to guide the search for new treatment strategies for chronic pain.