CONICET | Buscador de Institutos y Recursos Humanos

Bacterial resistance to antimicrobial agents is a growing public health concern. Even if the One Health concept invites us to consider companion animals as reservoirs of resistant strains, there is scarce information regarding resistance levels prevalent in household pets. In this work, we analyzed the susceptibility pattern of clinical E. coli (ECO) and Pseudomonas aeruginosa (PAE) isolates collected from felines or canines between Sep 2010 and Apr 2018 in Buenos Aires (Argentina). Inclusion criteria were all (n=9688) ECO or PAE recovered from different samples in this period. Susceptibility was evaluated by agar diffusion according to CLSI: ENR (enrofloxacin), NOR (norfloxacin), GEN (gentamicin), AMK (amikacin), AMC (amoxicillin-clavulanate), SAM (ampicillin-sulbactam), CEF (cefalotin), CTX (cefotaxime), NIT (nitrofurantoin) and TMS (trimethoprim-sulfamethoxazole), IMI (Imipenem) for ECO and IMI, AMK, PMB (polimixin B), CAZ (Ceftazidime), TZP (Piperacillin-Tazobactam), GEN, ENR, NOR for PAE. Records were analyzed with R Language for Statistical Computing.The recovered isolates were mostly from canine hosts (n=8404). ECO were more frequent (59%, n=5714) and associated with urine infections (p < 2e-16, OR: 14.86), while PAE (41%, n=3974) were likely related with ear infections (p < 2e-16, OR: 12.36). In addition to determine mean non-susceptibility (NS: Resistant and Intermediate) levels, we were able to establish temporal trends. Average NS levels of ECO were CEF: 55%, AMC: 39%, NOR and ENR: 38%, SAM: 37%, TMS: 35%, CTX: 19%, IMI: 0%, GEN: 16%, NIT: 8% and AMK: 1%. ECO showed a significant increase in NS to CEF: 2.05%, CTX: 1.52%, NOR: 1.72%, ENR: 0.81% per year. Inversely, significant decreases were found in GEN: -0.96% and TMS: -0.87% per year. No significant variation was detected in AMK, AMC, SAM and IMI (p

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