Clinical experience with thymoglobulin and antithymocyte globulin-fresenius as induction therapy in renal transplant patients: A retrospective study

CICORA, FEDERICO; MOS, FERNANDO; PAZ, MARTA; ROBERTI, JAVIER

EXPERIMENTAL AND CLINICAL TRANSPLANTATION

BASKENT UNIV

Año: 2013 vol. 11 p. 418 - 422

1304-0855

Objectives: We describe our experiences with, and compare the outcomes of, 2 groups of renal transplant patients treated with thymoglobulin or antithymocyte globulin-Fresenius as induction therapy at transplant to reduce the incidence of acute rejection and prevent delayed allograft function. Materials and Methods: Twenty-four recipients of deceased-donor or living-donor kidney transplants received thymoglobulin, and 23 patients received antithymocyte globulin-Fresenius. Patient and graft survival and efficacy and safety were assessed at 3 months. Results: The demographic characteristics of both groups were comparable, but the predominant donor type was significantly different. Incidence of complications, delayed graft function, and creatinine concentrations were comparable in both groups. At 3 months after the transplant, patient survival rate was 92% in the thymoglobulin group and 96% in the antithymocyte globulin-Fresenius group (P >. 05), and death-censored graft survival rate for both groups was not significantly different. Average hematocrit and lymphocyte, neutrophil, and platelet counts were comparable in both groups at 3 months´ follow-up. Average white blood count at 1 month was significantly different between the groups: at 5. 62 ± 2. 45 × 103 cells/mm3 in the thymoglobulin group and 7. 85 ± 4. 10 × 103 cells/mm3 in the ATG-F group (P