INVESTIGADORES
NERLI Bibiana Beatriz
artículos
Título:
Identification of the Cephalosporin Human Serum Albumin Binding Sites.
Autor/es:
NERLI, BIBIANA; PICÓ, GUILLERMO
Revista:
Pharmacology and Toxicology
Editorial:
P.J.D. Publications Ltd.
Referencias:
Lugar: Nueva York; Año: 1993 vol. 73 p. 297 - 300
ISSN:
0901-9928
Resumen:
We have demonstrated that the cephalosporins which possess heterozyclic pentagonal group substituents bind to the bilirubin binding site on albumin, while the cephalosporins which possess hexagonal hydrocarbon cycle substituents bind to the benzodizepine binding sites (site 11) on albumin. No binding of cephalosporins to the so-called site I and fatty acids binding site on human albumin was demonstrated.
