CHALCONES AS INHIBITORS OF PHYTOPATHOGENIC FUNGAL IN-VITRO DEVELOPMENT

CECILIA SANCHEZ; CARLOS ARDANAZ; MARÍA LAURA MASCOTTI; KURINA SANZ M.; ALEJANDRO A. ORDEN

San Luis

Congreso; XXVII Annual Scientific Meeting (Sociedad de Biología de Cuyo); 2009

Sociedad de Biología de Cuyo

In the search of novel antifungal compounds derived from natural products leads, a family of 22 chalcones was prepared in a “one step-one pot” procedure by condensation of methyl-aryl ketones and aryl-aldehydes, and characterized by mass spectrometry (MS). The antifungal activity of the family members was tested against the following series of phytopatogenic fungi: Six species of the Aspergillus genus (A. niger, A. terreus, A. flavus, A. parasiticus, A. candidum and A. fumigatus), two species of Penicillium (P. notatum and P. crysogenum) and Fusarium graminearum.The results obtained showed that the presence of a furane moiety as the B ring of the chalcone is an important characteristic for the tested bioactivity, since (E)-3-(furan-2-yl)-1-(thiophen-2-yl)prop-2-en-1-one and (E)-3-(furan-2-yl)-1-phenylprop-2-en-1-one resulted in the most active derivative toward most of the above-mentioned fungal strains. On the other hand, derivatives with a tiophene moiety as the A ring demonstrated selective activity against the tested Penicillium strains. Moreover, the activity of the basic structure (E)-chalcone against two strains of Aspergillus and two strains of Penicillium is promising.