SESQUITERPENE LACTONES AFFECT THE REDOX SYSTEM OF TRYPANOSOMA CRUZI

GOMEZ, J.; GUARISE, C.; TELLO FARAL, P.; ROBELLO, C.; CIFUENTE, DIEGO A.; SOSA, M.A.,; BARRERA, P.A.

Congreso; XXXVII Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2019

Chagas disease is caused by Trypanosoma cruzi (T. cruzi) and affects to millions of people worldwide, mostly in Latin America.The sesquiterpene lactone dehydroleucodine (DhL), is a trypanocidal molecule ?containing an alpha-methylene group which could reacts with sulfhydryl groups of key redox enzymes. This study was focused on elucidating the DhL mechanism of action , and extended to ten DhL derivatives (DC-X1 to DC-X10) obtained by chemical substitutions on the methylene group.