ANTI-INFLAMATORY ACTIVITY OF BACCHARIS MEDULLOSA DC., B ACCHARIS RUFESCENS AND CONYZA SOPHIIFOLIA IN MOUSE

CIFUENTE, D.A., SIMIRGIOTIS, M.J., FAVIER, S.L., ROTELLI, A.E., PELZER, L.E.

PHYTOTHERAPY RESEARCH

JOHN WILEY & SONS LTD

Lugar: CHICHESTER, UK; Año: 2001 vol. 15 p. 529 - 531

0951-418X

The antiinflammatory activities of ten organic extracts from the aerial parts of Baccharis medullosa DC., Baccharis rufescens S. and Laenecia sophiifolia (kunth) G. L. Nesom were investigated in mice subjected to carrageenan induced paw edema. Intraperitoneally administered organic extracts given at doses equivalent to 80 mg/kg of material inhibited the acute phases of inflammation in this model. Our results indicate that the most effective extracts were: n-hexane (I) from B. medullosa, acetone (V) and Chloroform (VII) from L. Sophiifolia, and acetone (VIII) and chloroform (X) from B. rufescens. All exerted the strongest effect at 5 h after injection of the phlogistic agent