Microbiological Baeyer-Villiger oxidation of 1-indanone with cultures of Aspergillus terreus

SERER MI; MORERA LP; CIFUENTE, D; KURINA SANZ MB; GIORDANO OS

Potrero de los Funes San Luis Argentina

Congreso; XXIV REUNIÓN CIENTÍFICA ANUAL DE LA SOCIEDAD DE BIOLOGÍA DE CUYO; 2006

Sociedad de Biología de Cuyo

17   Microbiological Baeyer-Villiger oxidation of 1-indanone with cultures of Aspergillus terreus Serer, M.I,  Morera, L.P., Cifuente, D.,  Kurina, M. and Giordano, O. INTEQUI-CONICET. Facultad de Qca, Bqca y Fcia. UNSL Chacabuco y Pedernera.. 5700. San Luis. E-mail: cifuente@unsl.edu.ar  Biological Baeyer-Villiger oxidations of ketones provide simple routes to obtained chiral lactones. These compounds are of great interest for the synthesis of natural products, pharmaceuticals and agrochemicals. This process constitutes a green chemistry alternative allowing enhanced safety and minimum environmental impact. In this work the microbiological Baeyer-Villiger oxidation using cultures of A. terreus (from ANLIS Dr. Malbran) was investigated. Biotransformation of 1-indanone was carried out in two step procedure. Resting cells were harvested from 48 h-old-cultures and suspended in pH 7 phosphate buffer. After 7 days of incubation the culture media was extracted with ethyl acetate. Blank assays were carried out. Each experience was performed three times with two replicates each. Biotransformation progress was analysed by GC. The oxidation product obtained with good yield was characterized by spectroscopic methods (1H and 13C NMR).