INVESTIGADORES
KURINA SANZ Marcela Beatriz
artículos
Título:
Thiol-free chemoenzymatic synthesis of β-ketosulfides
Autor/es:
HEREDIA, ADRIÁN A.; LÓPEZ-VIDAL, MARTÍN G.; KURINA-SANZ, MARCELA; BISOGNO, FABRICIO R.; PEÑÉÑORY, ALICIA B.
Revista:
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Editorial:
BEILSTEIN-INSTITUT
Referencias:
Año: 2019 vol. 15 p. 378 - 387
ISSN:
1860-5397
Resumen:
A preparation of β-ketosulfides avoiding the use of thiols is described. The combination of a multicomponent reaction and a lipase-catalysed hydrolysis has been developed in order to obtain high chemical diversity employing a single sulfur donor. This methodology for the selective synthesis of a set of β-ketosulfides is performed under mild conditions and can be set up in one-pot two-step and on a gram-scale.
