INVESTIGADORES
KURINA SANZ Marcela Beatriz
artículos
Título:
Stereo and regioselective hydroxylation of grindelic acid by Aspergillus niger
Autor/es:
ORDEN, A; CIFUENTE, D; BORKOWSKI, E; TONN, CE; KURINA SANZ MB
Revista:
NATURAL PRODUCT LETTERS
Editorial:
Harwood Academic Publisher
Referencias:
Lugar: San Diego. La Jolla. CA. USA; Año: 2005 vol. 19 p. 625 - 631
ISSN:
1057-5634
Resumen:
Stereo- and regioselective hydroxylation of grindelane derivatives on position 3b was catalyzed by cultures of Aspergillus niger sp. Grindelic acid (1), methyl grindelate (2), 15-hydroxy-7(8)-en-9a,13(S)-oxide-ent-labdane (3) and 7a,8a-epoxymethylgrindelate (4) were bioconverted in the corresponding 3b-hydroxy derivatives as the only biotransformation products. 13(S),15-dihydroxy-8(9)-en-ent-labdane (5) remained unreacted under the same conditions. Conformational and electronic studies of the substrates are discussed.
