PERSONAL DE APOYO
LOPEZ Gabriela Carina
artículos
Título:
Lack of Functional GABAB Receptors Alters Kiss1, Gnrh1 and Gad1 mRNA Expression in the Medial Basal Hypothalamus at Postnatal Day 4
Autor/es:
NOELIA P. DI GIORGIO; PAOLO N. CATALANO; PAULA V. LÓPEZ; SUSANA B. RULLI; SHEILA J. SEMAAN ; GABRIELA C. LÓPEZ; ALEXANDER S. KAUFFMAN; GUSTAVO M. SOMOZA; BERNHARD BETTLER; CARLOS LIBERTUN; VICTORIA A. LUX-LANTOS
Revista:
NEUROENDOCRINOLOGY
Editorial:
KARGER
Referencias:
Lugar: Basel; Año: 2013 vol. 98 p. 212 - 223
ISSN:
0028-3835
Resumen:
Abstract
BACKGROUND/AIMS:
Adult mice lacking functional GABAB receptors (GABAB1KO) show altered Gnrh1 and Gad1 expressions in the preoptic area-anterior hypothalamus (POA-AH) and females display disruption of cyclicity and fertility. Here we addressed whether sexual differentiation of the brain and the proper wiring of the GnRH and kisspeptin systems were already disturbed in postnatal day 4 (PND4) GABAB1KO mice.
