INVESTIGADORES
ERRA BALSELLS Rosa
congresos y reuniones científicas
Título:
Sulfoglycosphingolipids are biosynthesized by the intraerythrocytic stages of Plasmodium falciparum
Autor/es:
ERRA BALSELLS, ROSA; S COUTO, ALICIA; MASAE NISHIOKA,; HIROSHI NONAMI,; EMILIA KIMURA,; VALNICE PERES,; M KATZIN, ALEJANDRO
Lugar:
Honolulu
Reunión:
Congreso; US/Japan Glyco 2004, Annual Conference of The Society for Glycobiology / Japanese Society for Carbohydrate Research,; 2004
Institución organizadora:
Society for Glycobiology / Japanese Society for Carbohydrate Research,
Resumen:
Plasmodium falciparum is one of the world´s most pathogenic microbes, it kills millions annually. Lipid metabolism has been attracting a lot of attention in the last years with respect to basic biology and applications for malaria chemoterapeutic purposes. Recently, we have shown the structural determination of malarial neutral glycosphingolipids. Among acidic glycolipids, gangliosides and sulfoglycolipids are usually found as membrane components, however, previous reports have shown that P. falciparum does not biosynthesize sialic acid. In this work we have performed metabolic incorporation of [14C]palmitic acid, [14C] glucose and Na235SO4 in the three intraerythrocytic stages of P. falciparum in order to determine the presence of sulfoglycolipids.
