INVESTIGADORES
LUNA Julio Alberto
artículos
Título:
Hydrophilic and hydrophobic interactions in cross-linked chitosan membranes
Autor/es:
LUCIANO MENGATTO; MARÍA GRACIELA FERREYRA; AMELIA RUBIOLO; IGNACIO RINTOUL; JULIO LUNA
Revista:
MATERIALS CHEMISTRY AND PHYSICS
Editorial:
ELSEVIER SCIENCE SA
Referencias:
Lugar: Amsterdam; Año: 2013 vol. 139
ISSN:
0254-0584
Resumen:
Chitosan membranes with different cross-linking density were prepared by modifying cross-linking
time. Sodium tripolyphosphate was the cross-linking agent. A pulsed nuclear magnetic resonance
study was performed on uncross-linked and cross-linked membranes. Different fraction of water molecules
were identified in different zones within the membranes. The ratio of water molecules per chitosan
repeating unit were calculated. A maximum of twelve water molecules were tightly coordinated to
the chitosan repeating unit. Also, a very small water molecule fraction was identified but it was mobile
enough as not to contribute to the dipolar interactions. The cross-linking reaction could lead to the
formation of hydrophilic and hydrophobic interactions. These two types of interactions could result in
the coexistence of a network formed by hydrophilic and hydrophobic micropores. This knowledge could
be useful for the interpretation of results of hydrophobic drugs permeation across hydrophilic membranes.
For example, the increment of estradiol fluxes across chitosan membranes with an increase in
cross-linking density.fied in different zones within the membranes. The ratio of water molecules per chitosan
repeating unit were calculated. A maximum of twelve water molecules were tightly coordinated to
the chitosan repeating unit. Also, a very small water molecule fraction was identified but it was mobile
enough as not to contribute to the dipolar interactions. The cross-linking reaction could lead to the
formation of hydrophilic and hydrophobic interactions. These two types of interactions could result in
the coexistence of a network formed by hydrophilic and hydrophobic micropores. This knowledge could
be useful for the interpretation of results of hydrophobic drugs permeation across hydrophilic membranes.
For example, the increment of estradiol fluxes across chitosan membranes with an increase in
cross-linking density.fied but it was mobile
enough as not to contribute to the dipolar interactions. The cross-linking reaction could lead to the
formation of hydrophilic and hydrophobic interactions. These two types of interactions could result in
the coexistence of a network formed by hydrophilic and hydrophobic micropores. This knowledge could
be useful for the interpretation of results of hydrophobic drugs permeation across hydrophilic membranes.
For example, the increment of estradiol fluxes across chitosan membranes with an increase in
cross-linking density.fluxes across chitosan membranes with an increase in
cross-linking density.