INVESTIGADORES
LUNA Julio Alberto
artículos
Título:
Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance
Autor/es:
IGNACIO M. HELBLING; DRA. MARÍA I. CABRERA; DR. JULIO A. LUNA
Revista:
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2011 p. 288 - 298
ISSN:
0928-0987
Resumen:
A mathematical modeling of controlled release of drug from one-layer and two-layer torus-shaped
devices with external mass transfer resistance is presented. Analytical solutions based on the pseudosteady
state approximation are derived. The validity of the equations is established in two stages. In
the first stage, the validity of the models derived for more complex systems is determined by comparison
with profiles predicted by the simplest model, in asymptotic cases. In the second stage, the reliability and
usefulness of the models are ascertained by comparison of the simulation results with vaginal rings
experimental release data reported in the literature. In order to measures quantitatively the fit of the theoretical
models to the experimental data, the pair-wise procedure is used. A good agreement between the
prediction of the models and the experimental data is observed. The models are applicable only to torusshaped
systems in where the initial load of drug is higher than its solubility in the polymer.