Synthesis, biological evaluation and study of in vitro pharmacokinetic properties of antiviral agents against dengue

LEAL, EMILSE S.; FERNANDEZ, G.A.; BATTINI, L.; ADLER, NATALIA S; AUCAR, MARÍA G.; VIDELA, M.; MONGE, MARÍA E.; CAVASOTTO, CLAUDIO N; BOLLINI, M.

Buenos Aires

Congreso; Drug Discovery for Neglected Diseases International Congress 2018; 2018

Dengue disease is an infection caused by dengue virus (DENV), which is transmitted by mosquitoes of the genus Aedes. At present, no specific antiviral therapy or effective vaccine is available to control this disease. Therefore, new approaches are required to prevent replication, pathogenesis and viral transmission. The DENV particle comprises a lipid membrane and an envelope glycoprotein E, which interacts with specific receptors on the surface of the host cell, enabling its entry. The crystal structure of the E protein of DENV-2 revealed a hydrophobic pocket occupied by a detergent molecule n-octyl-β-D-glucoside (β-OG).1 This allows the development of small molecules that potentially bind to the β-OG pocket and inhibit the process of viral entry.