INVESTIGADORES
PUETA Mariana
artículos
Título:
Prenatal and postnatal ethanol experiences modulate consumption of the drug in rat pups, without impairment in the granular cell layer of the main olfactory bulb.
Autor/es:
PUETA MARIANA; ROVASIO ROBERTO A; ABATE PAULA; SPEAR NORMAN E; MOLINA JUAN C
Revista:
PHYSIOLOGY AND BEHAVIOR
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2011 vol. 102 p. 63 - 75
ISSN:
0031-9384
Resumen:
-The effect of
moderate exposure to ethanol during late gestation was studied in terms of its
interaction with moderate exposure during nursing from an intoxicated dam. A
further issue was whether behavioral effects of ethanol, especially the
enhanced ethanol intake known to occur after moderate ethanol prenatally or
during nursing, depend upon teratological effects that may include death of
neurons in the main olfactory bulb (MOB). During gestational days 17-20 rats
were given 0, 1 or 2 g/kg ethanol doses intragastrically (i.g.). After
parturition these dams were given a dose of 2.5 g/kg ethanol i.g. each day and
allowed to perform regular nursing activities. During postnatal days (PDs) 15
and 16, ethanol intake of pups was assessed along with aspects of their general
activity. In a second experiment pups given the same prenatal treatment as
above were tested for blood ethanol concentration (BEC) in response to an
ethanol challenge on PD6. A third experiment (Exp. 2b) assessed stereologically
the number of cells in the granular cell layer of the MOB on PD7, as a function
of analogous pre- and postnatal ethanol exposures. Results revealed that
ethanol intake during the third postnatal week was increased by prenatal as
well as postnatal ethanol exposure, with a few interesting qualifications. For
instance, pups given 1 g/kg prenatally did not have increased ethanol intake
unless they also had experienced ethanol during nursing. There were no effects
of ethanol on either BECs or conventional teratology (cell number). This
increases the viability of an explanation of the effects of prenatal and early
postnatal ethanol on later ethanol intake in terms of learning and memory-