METABOTROPIC GLUTAMATE RECEPTOR 3 - SAPPα: NOVEL PATHWAY IN CLASS-A SCAVENGER RECEPTOR-MEDIATED β-AMYLOID CLEARANCE BY ASTROCYTES

DANIELA DURAND; TURATI, JUAN; CARNIGLIA, LILA; DELIA RAMÍREZ; JULIETA SABA; CARLA CARUSO; VON BERNHARDI, ROMMY; LASAGA, MERCEDES

Congreso; Reunion Anual de SAIC; 2017

Among metabotropic glutamate receptors (mGluR), astroglial mGlu3R subtype has particularly shown a broad range of neuroprotective functions. Our previous results demonstrated that mGlu3R activation by the synthetic agonist LY379268 promotes non-amyloidogenic APP cleavage, thereby releasing sAPPα neuroprotective fragment from astrocytes. Moreover, sAPPα mediates the antiapoptotic effect of conditioned medium from LY379268-treated astrocytes (LY-ACM) against Aβ toxicity in hippocampal neurons. We also showed that LY379268 increases Aβ uptake by astrocytes, which parallels the reduction inco-cultured neuron death. In order to elucidate the mechanism involved in Aβ uptake by astrocytes, the present study shows that LY-ACM increased HiLyte Fluor-Aβ25-35 uptake by naïve astrocytes (p