Subtype 3 metabotropic glutamate receptor-induced amyloid-beta clearance by glial cells

DURAND, DANIELA; LILA CARNIGLIA; DELIA RAMÍREZ; TURATI, JUAN; JULIETA SABA; CARLA CARUSO; LASAGA, MERCEDES

CABA

Congreso; Federation of Latin American and Caribbean Neuroscience Societies; 2016

Previous results from our group reveal that stimulation of astroglial mGlu3 receptors promotes the non?amyloidogenic cleavage of amyloid precursor protein. This action implies both increased neurotrophic sAPPa peptide levels and decreased Ab production. But anti-amyloid effects of glial mGlu3R are not restricted to the Ab synthesis pathway. Indeed, we show here that Ab clearance is also regulated by these receptors. mGlu2/3R agonist LY379268 (0.1 uM) induced both microglial ingestion of latex beads (p