BECAS
SABA Julieta
congresos y reuniones científicas
Título:
Administration of mGlu2/3R agonist in a model of chronic cerebral hypoperfusion
Autor/es:
TURATI, JUAN; AMANDA NUNES SANTIAGO; CARNIGLIA, LILA; JULIETA SABA; CARLA CARUSO; DANIELA DURAND; MARIA WEFFORT DE OLIVEIRA; LASAGA, MERCEDES
Reunión:
Congreso; Reunion Anual de sociedades de biociencia; 2019
Institución organizadora:
SAIC
Resumen:
Chronic cerebral hypoperfusion (CCH) resembles central changes in aging-related vascular dementias and Alzheimer´s disease (AD). Our group has demonstrated, in vitro, that astroglial subtype 3 metabotropic glutamate receptors (mGlu3R) present protective actions against neurotoxic agents including A. However, contradictory results were reported when mGlu3R ligands were administered in vivo We examined the effect of the mGlu2/3R agonist, LY376298 (LY) 1mg/kg i.p., in middle aged rats with CCH. The effect of mGlu2/3R agonist in neuron cell death and glial activation of the hippocampus were determined by immunohistochemistry. Moreover, the expression of GRM2, GRM3 (mGlu2/3R genes), GFAP and BDNF was studied by RT-qPCR technique. NeuN expression presents a decreased in CCH animals (p