Effect of systemic administration of mGlu3R agonist in a model of cerebral ischemia

TURATI, JUAN; AMANDA NUNES SANTIAGO; DELIA RAMÍREZ; CARNIGLIA, LILA; JULIETA SABA; CARLA CARUSO; DANIELA DURAND; MARIA WEFFORT DE OLIVEIRA; LASAGA, MERCEDES

Cordoba

Congreso; Reunión Anual de la Sociedad Argentina de Neurociencia; 2018

SAN

Chronic cerebral hypoperfusion (CCH) resembles central changes in aging-related vascular dementias and Alzheimer´s disease (AD). Our group has demonstrated, in vitro, that astroglial subtype 3 metabotropic glutamate receptors (mGlu3R) present protective actions against neurotoxic agents including A. However, contradictory results were reported when mGlu3R ligands were administered in vivoWe examined the effect of the mGlu3R agonist, LY376298 (LY) 1mg/kg i.p., in middle aged rats with CCH. Memory retention was evaluated using the aversive radial maze and NeuN and GFAP expression were determined by immunohistochemistry.All groups showed increased latency and number of reference memory after surgery (p