L-3,4-dihydroxyphenylalanine (L-DOPA) Modulates the Function of Corticotrophs

SANTIAGO JORDI ORRILLO; NATALY DE DIOS; FERNANDA DE FINO; JIMENA FERRARIS; DANIEL PISERA

Ciudad Autónoma de Buenos Aires

Congreso; LXII Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2017

L-Dopa plus peripheral inhibitors of aromatic L-amino acid decarboxylase (AADC) is the treatment intended to alleviate the motor symptoms of Parkinson?s disease (PD). However, in patients this chronic treatment has been described to alter the secretion of ACTH, probably generating an inadequate neuroendocrine stress response. In the present research, we aimed to understand the actions of L-Dopa in the corticotroph function. In first place, we determined the effects of L-Dopa and its decarboxylation to Dopamine (DA) by AADC on ACTH secretion. We observed that L-Dopa decreases ACTH secretion in vitro (p