Alzheimer’s disease risk after COVID-19: a view from the perspective of the Infectious Hypothesis of neurodegeneration

EUGENIA OLIVERA; ALBANY SÁEZ; LILA CARNIGLIA; CARLA CARUSO; MERCEDES LASAGA; DANIELA DURAND

NEURAL REGENERATION RESEARCH

SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES

Año: 2023 p. 1404 - 1410

1673-5374

In the light of the rising evidence of the association between viral and bacterial infections andneurodegeneration, we aimed at revisiting the Infectious Hypothesis of Alzheimer’s disease (AD) and analyzing the possible implications of COVID-19 neurological sequelae in long-term neurodegeneration. We wondered how SARS-CoV-2 could be related to the Amyloid-β cascade and how it could lead to the pathological hallmarks of the disease. We also predict a paradigm change in clinical medicine, which now has a great opportunity to conduct prospective surveillance of cognitive sequelae and progression to dementia in people who suffered severe infections together with other risk factors for AD.