INVESTIGADORES
MORI SEQUEIROS GARCIA Maria De Las Mercedes
artículos
Título:
Reactive oxygen species mediate dopamine-induced signaling in renal proximal tubule cells
Autor/es:
ACQUIER AB; MORI SEQUEIROS GARCÍA MM; GOROSTIZAGA AB; PAZ C; MENDEZ CF
Revista:
FEBS LETTERS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2013
ISSN:
0014-5793
Resumen:
Intrarenally-produced dopamine (DA) induces a large increase in urinary sodiumexcretion mainly due to the inhibition of tubular sodium reabsorption. We aimed tostudy the participation of reactive oxygen species (ROS) in DA signaling pathway inproximal tubule cells. Our results show that DA increased ROS production in OK cellsand indicate the mitochondria as the main source of ROS. DA also increased ERK1/2,superoxide dismutase (SOD) and transcription factor kB (NF-kB) activity. Thesefindings suggest that DA generates mitochondria-derived ROS that activate ERK1/2and subsequently NF-kB and SOD activity at concentrations that exert a physiologicalregulation of renal function.
