INVESTIGADORES
ZARATE Sandra Cristina
congresos y reuniones científicas
Título:
Prolactin induces apoptosis of lactotropes regulating anterior pituitary cell turnover along the estrous cycle
Autor/es:
FERRARIS JIMENA; ZÁRATE SANDRA; JAITA GABRIELA; BOUTILLON FLORENCE; BERNADET MARIE; AUFFRET JULIEN; SEILICOVICH ADRIANA; BINART NADINE; GOFFIN VINCENT; PISERA DANIEL
Lugar:
Chicago
Reunión:
Congreso; 16th International Congress of Endocrinology and Endocrine Society's 96th Annual Meeting; 2014
Institución organizadora:
Endocrine Society
Resumen:
In females, anterior pituitary (AP) cell turnover is hormone- regulated along the estrous cycle. In the rat, the proestrus surge of PRL coincides with the highest apoptosis and the lowest proliferation rates [1]. As PRL acts as a proapoptotic and antiproliferative factor in the male AP [2], we hypothesized that PRL is involved in the control of AP cell turnover along the estrus cycle. PRL administration to ovariectomized (OVX) rats (1 mg/Kg, i.p, 6 h) increased the percentage of hypodiploid cells (C: 10.0 ± 1.1, PRL 21.9 ± 5.3, p
