Rol of estrogen-related receptor alpha and estrogen receptor alpha on transcriptional regulation of Acyl-CoA synthetase 4 in breast cancer cells

DATTILO MELINA; BENZO YANINA; LOPEZ PAULA; HERRERA, LUCIA; PRADA, JESICA; ORLANDO ULISES; CASTILLO, ANA FERNANDA; MALOBERTI, PAULA MARIANA

Congreso; LXIV Reunión anual de la sociedad argentina de investigaciones clínicas; 2019

Acyl-CoA synthetase 4 (ACSL4)overexpression plays a causal role in the aggressiveness of triplenegative breast cancer (TNBC). In turn, a negative correlationhas been established between ACSL4 and estrogen receptoralpha (ER) expression. Our hypothesis is that transcriptionalregulation is involved in the differential expression of ACSL4 inbreast cancer cells. We observed that TNBC cells (MDA-MB-231and Hs578T) exhibit greater activity of ACSL4 promoter thanER+ cell lines (MCF-7 and T47D) (p