Mitochondrial peptide Humanin enhances chemoresistance of glioblastoma cells

C.ZUCATTO; A.ASAD; A.NICOLA CANDIA; S.SAGRIPANTI; A.ABT; M.PIDRE; V.ROMANOWSKI; A. SEILICOVICH; M.CANDOLFI

Congreso; LXIII Reunión de la Sociedad Argentina de Investigación Clínica; 2018

The mitochondrial-derived peptide Humanin (HN) exerts potent cytoprotective effects in several normal and tumoral cells. However, the role of this peptide in tumor pathogenesis is not well understood. Glioblastoma multiforme (GBM) is the most common and aggressive primary brain cancer. We aimed to evaluate whether HN affects the sensitivity of GBM cells to chemotherapy. We observed expression of HN in rat C6 GBM cells by inmunofluorescence. We determined the effect of HN in the response of GBM cells to cytotoxic stimuli. HN (10 µM) inhibited the effect of serum deprivation, Cisplatin (CP, 2 µM) and Temozolomide (100 µM) on the viability of C6 cells (MTT, t test, *p