Negative inotropic activity of anti-laminin IgG : participation of cholinergic mechanisms.

BACMAN, S.; BORDA, E.; DENDUCHIS, B.; LUSTIG, L.; STERIN-BORDA, L.

BRITISH JOURNAL OF PHARMACOLOGY

WILEY-BLACKWELL PUBLISHING, INC

Año: 1989 vol. 97 p. 377 - 382

0007-1188

1 Antilaminin IgG decreased the dF/dt of mouse isolated atria and inhibited the mechanical effect of acetylcholine in a non-competitive fashion. 2 Inhibitors of nicotinic and muscarinic cholinoceptors impaired the negative inotropic action of antilaminin IgG in mouse  isolated atria. Hemicholinium and tetrodotoxin also reduced the response  while the antihistamine, pyrilamine was without effect.of mouse isolated atria and inhibited the mechanical effect of acetylcholine in a non-competitive fashion. 2 Inhibitors of nicotinic and muscarinic cholinoceptors impaired the negative inotropic action of antilaminin IgG in mouse  isolated atria. Hemicholinium and tetrodotoxin also reduced the response  while the antihistamine, pyrilamine was without effect.the negative inotropic action of antilaminin IgG in mouse  isolated atria. Hemicholinium and tetrodotoxin also reduced the response  while the antihistamine, pyrilamine was without effect. 3 These results suggest that antilaminin IgG modulates cholinergic function in mouse  isolatedsuggest that antilaminin IgG modulates cholinergic function in mouse  isolated atria. Possible mechanisms are discussed. discussed.