Covalent binding of carbon tetrachloride reactive metabolites to liver microsomal and nuclear lipid and phospholipid classes from Sprague Dawley and Osborne Mendel male rats.

SL FANELLI; JA CASTRO.

TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS

Wiley-Liss Inc

Lugar: Oxford; Año: 1995 vol. 15 p. 155 - 166

0270-3211

The interaction between carbon tetrachloride (CCl4)-reactive metabolites and liver microsomal or nuclear lipids covalent binding (CB) was studied in male rats from Osborne Mendel (OM) and Sprague Dawley (SD), strains with different cancer susceptibility. The in vitro or in vivo CB was more intense in OM than in SD. Most of the CB was with phospholipid (PL; SD > OM). The CB to cholesterol (CH) and cholesterol esters (CHE) was OM > SD. We also observed the presence of specific adducts only present in lipids from either OM or SD strains. The results were related to the well-known role of PL and CH derivatives in gene function control and cell growth.