Haloperidol administered exclusively during the striatal critical period (postnatal days 30-37) alters circling motor behavior in rat adulthood

SOIZA REILLY, M; AZCURRA, JM

Pinamar

Congreso; 20th Meeting of the Argentinean Society for Neurochemistry and 10th of Panamerican Association for Biochemistry and Molecular Biology; 2005

SAN y PABMB

Duringrat striatum postnatal (PN) development exist a critical period (PN30-37) ofactivity-dependent plasticity. Circular motor activity developed in CirclingTraining (CT) during this period elicits a permanent drop of ~45% indopaminergic D2 receptors expression. Here, we have studied long-lasting motorbehavioral alterations elicited by the antipsychotic drug haloperidol (D2antagonist) administered at clinically relevant doses before (PN 20-27), during(PN 30-37) or after (PN 40-47) striatal critical period. Male rats SpragueDowley were treated between PN 20-27, PN 30-37 or PN 40-47 with haloperidol(i.p. 0,7 o 2,5 mg/kg/day) or physiological solution (control). Then, we havetested motor performance in CT during adulthood (PN 90). Rats treated withhaloperidol during the critical period exhibits exacerbated motor response inCT in respect to control animals  forboth doses (p<0,01). In contrast, drug administered before or after critical period have not shown alterationsin circling behavior. These results uncovers a particular susceptibility periodto the known haloperidol effects during postnatal development with permanencein adulthood.