INVESTIGADORES
SOIZA REILLY Mariano
congresos y reuniones científicas
Título:
Gating of excitation in the dorsal raphe nucleus by GABA
Autor/es:
MARIANO SOIZA REILLY; WAYNE B. ANDERSON; CHRISTOPHER W. VAUGHAN; KATHRYN G. COMMONS
Lugar:
Lyon
Reunión:
Congreso; French Society for Neuroscience Meeting; 2013
Institución organizadora:
French Society for Neuroscience
Resumen:
The dorsal raphe nucleus (DR) controls forebrain serotonin
neurotransmission to influence emotional states. GABA neurotransmission
in the DR has been implicated in regulating sleep/wake states and
influencing anxiety and aggression. To gain insight into how GABA
regulates DR activity, we analyzed the organization of both GABA and
glutamate axons in the rat DR using a high-resolution immunofluorescence
technique, array tomography, as well as EM. This analysis revealed that
a third or more of GABA-containing axons are organized in synaptic
triads with a glutamatergic axon and a common postsynaptic target.
Electrophysiological recordings showed that GABA has the capacity to
presynaptically gate glutamate release in the DR through a combination
of GABA-A and GABA-B receptor-mediated effects. Thus, GABA-glutamate
synaptic triads are a common feature of the network architecture of the
DR with the potential to regulate excitation of the nucleus.