INVESTIGADORES
DE LA MATA Manuel
artículos
Título:
RNA Polymerase II Elongation at the Crossroads of Transcription and Alternative Splicing.
Autor/es:
DE LA MATA, M., MUÑOZ, M.J., ALLÓ, M., FEDEDA, J. P., SCHOR, I.E., AND KORNBLIHTT, A.R.
Revista:
Genetics Research International
Editorial:
Hindawi Publishing Corporation
Referencias:
Lugar: New York; Año: 2011 p. 1 - 9
ISSN:
2090-3162
Resumen:
The elongation phase of transcription lies at the core of several simultaneous and coupled events leading to alternative splicing regulation. Although underestimated in the past, it is at this phase of the transcription cycle where complexes affecting the transcription machinery itself, chromatin structure, posttranscriptional gene regulation and pre-mRNA processing converge to regulate each other or simply to consolidate higher-order complexes and functions. This paper focuses on the multiple processes that take place during transcription elongation which ultimately regulate the outcome of alternative splicing decisions.
