INVESTIGADORES
DE LA MATA Manuel
artículos
Título:
The carboxy terminal domain of RNA polymerase II and alternative splicing.
Autor/es:
MUÑOZ, M.J., DE LA MATA, M., AND KORNBLIHTT, A.R.
Revista:
TRENDS IN BIOCHEMICAL SCIENCES
Editorial:
ELSEVIER SCIENCE LONDON
Referencias:
Lugar: Londres; Año: 2010 vol. 35 p. 497 - 504
ISSN:
0968-0004
Resumen:
Alternative splicing is controlled by cis-regulatory sequences present
in the pre-mRNA and their cognate trans-acting factors, as well as by
its coupling to RNA polymerase II (pol II) transcription. A unique
feature of this polymerase is the presence of a highly repetitive
carboxy terminal domain (CTD), which is subject to multiple regulatory
post-translational modifications. CTD phosphorylation events affect the
transcriptional properties of pol II and the outcome of
co-transcriptional alternative splicing by mediating the effects of
splicing factors and by modulating transcription elongation rates. Here,
we discuss various examples of involvement of the CTD in alternative
splicing regulation as well as the current methodological limitations in
deciphering the detailed mechanisms of this process.