Memory rectivation beyond expression: Increments of HSP70 triggered by memory reactivation in the protocerebrum of Chasmagnathus

GABRIELA V. NIEVA; KARINA A. BARREIRO; LUIS D. SUÁREZ; JOSÉ CLEMENTE; ENRIQUE L. PORTIANSKY ; ALEJANDRO DELORENZI

Huerta Grande, Córdoba

Congreso; XXVII COGRESO ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN EN NEUROCIENCIAS & Reunión Satélite / Neurobiología del Comportamiento: ?Neuroetología y Neurobiología de la Memoria en el Cono Sur?; 2013

SOCIEDAD ARGENTINA DE INVESTIGACIÓN EN NEUROCIENCIAS

The reconsolidationhypothesis has challenged the traditional view of consolidation, including thenotion that new memories are fixed and established. Previous studies of the labsupport the idea that there is dissociation between the mechanisms that mediatememory reactivation and the ones that mediate behavioral expression of memory.Our group has shown, in the Lateral. Protocerebrum (LP) in Chasmagnathus ,neural changes induced by different training protocols correlate with memorypersistence (evaluated as the capacity of memory to be reactivated and becomelabile) but not with the long-term expression of the reactivated memory. Thecentral hypothesis of this Master?s Thesis project is that memory reactivationinduces neuronal activity patterns in LP regardless memory expression. The goalis to show that memory built up after a weak training protocol can bereactivated even when long-term memory (LTM) formed by this training remainsunexpressed. Using HSP 70 as a neuronal activity marker in LP we are evaluatingwhether unexpressed memories are reactivated, which will add evidence to theview that reactivation occurs independently of the expression of memory.Preliminary results show that memory reactivation of a consolidated butunexpressed memory induces, in small neuropils of the LP, an increase in HSP70immunoreactivity.