Transcriptional elongation and alternative splicing

GWENDAL DUJARDINCELINA LAFAILLEEZEQUIEL PETRILLOVALERIA BUGGIANOLUCIANA I. GÓMEZ ACUÑAANA FISZBEINMICAELA A. GODOY HERZNICOLÁS NIETO MORENOMANUEL J. MUÑOZMARIANO ALLÓIGNACIO E. SCHORALBERTO R. KORNBLIHTT

BIOCHIMICA AND BIOPHYSICA ACTA

elsevier

Año: 2013 vol. 1829 p. 134 - 140

0006-3002

Alternative splicing has emerged as a key contributor to proteome diversity, highlighting the importance ofunderstanding its regulation. In recent years it became apparent that splicing is predominantly cotranscriptional,allowing for crosstalk between these two nuclear processes. We discuss some of the links between transcriptionand splicing, with special emphasis on the role played by transcription elongation in the regulation of alternativesplicing events and in particular the kinetic model of alternative splicing regulation.This article is part of a SpecialIssue entitled: RNA polymerase II Transcript Elongation.