INVESTIGADORES
MEDAN Violeta
congresos y reuniones científicas
Título:
A computational model on the goldfish Mauthner cell
Autor/es:
MÄKI-MARTTUNEN, TUOMO; MEDAN, VIOLETA
Lugar:
Huerta Grande, Córdoba
Reunión:
Congreso; XXVIII CONGRESO ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACION EN NEUROCIENCIAS & Reunión satélite sobre Neurobiología del Comportamiento: ?NeuroetologÍa y Neurobiología de la Memoria en el cono sur? Un homenaje a Héctor Maldonado; 2013
Institución organizadora:
Sociedad Argentina de Neurociencias
Resumen:
Integration of multimodal information is of key importance to generate adaptive
behavior. However, our understanding of how multimodal integration is
implemented at the dendritic level is still scant. We address this question in the
Mauthner-cell, the ?decision making element? of the startle escape network of
goldfish. The Mauthner-cell has two main dendritic branches, lateral and ventral,
where the former receives auditory input and the latter input from the visual
system. Both dendrites are amenable to intracellular recording in vivo. Here, we
used a Hodgkin-Huxley type of model with three voltage-gated ionic channels (one
Na+ and two K+ channels) combined with an approximate model of the cell
morphology to describe the cell behavior. We fitted the model parameters to
intracellular recordings using two types of data: 1) Square pulses injected
intracellularly at soma, and responses measured at the proximal lateral dendrite,
and 2) Short excitatory pulses injected extracellularly at distal parts of the axon to
induce an antidromic action potential, measured at the soma and several different
locations along the dendrites. This model provides a simulation framework for
testing the cell response to electrical input. Moreover, it will allow us to explore
the conditions for successful signal propagation in the cell, such as determining
whether purely passive dendrites are enough to explain its electrical behavior or if
voltage-gated ion channels are necessary to describe it.