INVESTIGADORES
SCHOR Ignacio Esteban
artículos
Título:
When chromatin meets splicing
Autor/es:
KORNBLIHTT AR; SCHOR IE; ALLO M; BLENCOWE BJ
Revista:
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Editorial:
NATURE PUBLISHING GROUP
Referencias:
Año: 2009 vol. 16 p. 902 - 903
ISSN:
1545-9985
Resumen:
Using bioinformatics analysis of previously published global genome deep-sequencing data, two papers now show that DNA sequences associated with nucleosomes are preferentially located in exons. The correlation between nucleosome distribution and the exon-intron organization of genes may have a key role in exon recognition at the pre-mRNA level during co-transcriptional splicing, consistent with previous findings indicating chromatin-mediated regulation of alternative splicing.
