INVESTIGADORES
WEISSMANN Carina
artículos
Título:
Mechanisms of Neurodegenerative Diseases: Insights From Live Cell Imaging
Autor/es:
CARINA WEISSMANN; ROLAND BRANDT
Revista:
JOURNAL OF NEUROSCIENCE RESEARCH
Editorial:
Wiley InterScience
Referencias:
Año: 2008 vol. 86 p. 504 - 511
ISSN:
0360-4012
Resumen:
Pathologic alterations in protein dynamics such as
changes in protein degradation, accumulation of
misfolded proteins, and deficits in cellular transport
mechanisms are a common feature of most if not all
neurodegenerative diseases. Live cell imaging studies
promise to contribute to a better understanding of the
molecular mechanisms underlying these diseases by
visualizing the turnover, accumulation, and transport of
proteins in a living cellular context in real time. In this
review, we discuss recent work in which different live
cell imaging approaches are applied in cellular models
of amyotrophic lateral sclerosis, polyQ diseases, and
tauopathies as paradigmatic examples of diseases with
different types of alterations in protein dynamics. It
becomes evident that live cell imaging studies provide
new insights into different aspects of protein dynamics,
such as the understanding that aggregates are not as
static as concluded from previous studies but exhibit a
remarkable molecular exchange and that the dynamicity
state of the neuronal cytoskeleton might have a critical
role in neuronal degeneration. It can be anticipated
that live cell imaging studies will lead to a more
dynamic view of protein turnover and aggregation,
which may aid in identifying drugs that specifically
interfere with disease-related changes. VVC 2007 Wiley-
Liss, Inc.
Liss, Inc.
VVC 2007 Wiley-
Liss, Inc.
Key words: amyotrophic lateral sclerosis; polyQ disease;
tauopathy; protein aggregation; axonal transport
tauopathy; protein aggregation; axonal transport
amyotrophic lateral sclerosis; polyQ disease;
tauopathy; protein aggregation; axonal transport